Synthesis and degranulation-inhibiting activities of the proposed apteniols B, C, and G

Abstract

The synthesis of compounds with the structures proposed for the oxyneolignan apteniols B, C, and G is described. The diphenyl ether skeletons of the proposed apteniols were formed via Ullmann ether synthesis. In particular, the spectral data for the synthesized apteniols B, C, and G did not agree with those previously reported for the isolated compounds. Furthermore, the synthesized proposed apteniol B did not show degranulation-inhibiting activity, while the prepared proposed apteniols C and G exhibited activities considerably weaker than that of the methyl ester of proposed apteniol A.

Graphical Abstract

The synthesis of proposed apteniols B, C, and G is described. The spectral data of the synthesized apteniols B, C, and G did not agree with those of isolated compounds.

Key words:

• Aptenia cordifolia
• oxyneolignan
• Ullmann ether synthesis
• apteniol, degranulation-inhibiting activity

Acknowledgments

The authors would like to thank Enago (www.enago.jp) for the English language review.