Vroman effects, techniques, and philosophies

Abstract

Leo Vroman's work on blood-materials interaction over the years has motivated and influenced much of our work in this field. Here we show how most of our studies on proteins at interfaces can be traced to Vroman's ideas presented in Blood over 25 years ago. Specifically, we briefly discuss simple proteins at simple interfaces, complex interfaces, complex proteins at interfaces, multi-parameter phenomena, and scientific communication and education.

Keywords:

• Vroman effects
• blood
• protein adsorption
• competitive adsorption
• gradient surfaces
• denaturation