Study of the degradation mechanisms of oxidized Cellulose-Derivative hemostatic agent by using model compound

Abstract

Degradable hemostatic agents are the essential materials for controlling the hemorrhage. Hemostatic oxidized cellulose carboxylate sodium fiber (OCCSF) has been synthesized via a simple neutralization reaction between water-insoluble oxidized cellulose fiber (OCF) and NaOH. Importantly, the degradation mechanisms of OCCSF have been investigated in vitro assay. Chemical structure of the material is tested by using FT-IR and NMR, and no obvious change was detected before and after degradation. Degree of polymerization (DP) of OCCSF declines with prolonging the degradation period, accompanying with the decrease in carboxyl content (CC), so that it could be concluded that OCCSF may undergo decarboxylation degradation process. Besides, combined the change of fiber color with UV, another elimination degradation mechanism of OCCSF could be deduced, and this has been demonstrated using 1,2-cyclohexanedione as the model compound.

Keywords:

• Oxidized cellulose carboxylate sodium fiber
• degradation mechanism
• decarboxylation reaction
• elimination reaction
• model compound

Acknowledgements

This work was financilly supported by China Postdoctoral Science Foundation (2013M541372). We would like to thank the financial support from Heilongjiang Postdoctoral Fund (LBH-Z13086). This work was also supported by “The Fundamental Research Funds for the Central Universities” (Grant No. HIT. NSRIF2015047).