Shape memory materials promoting cell adhesion and tissue invasion towards the applications requiring minimally invasive implantation

Abstract

Minimally invasive implantation of porous implants with large volume for in vivo filling proposes high requirements for material preparation. Porous scaffolds based on shape memory polymer (SMP) possess great potential for being delivered as the compact form via minimally invasive surgery. Here, poly (ε-caprolactone)-dienes (PCL-dienes) and crylic acid (AA) were polymerized and cross-linked to fabricate SMP scaffolds, the porous structure of which was created through particle leaching method. Three scaffolds, PAA-PCL20, PAA-PCL50 and PAA-PCL80 were fabricated with different content of PCL-dienes, possessing similar pore size (350 μm) and porosity (85%). PAA-PCL50 scaffold had a T_m of 38 °C, exhibiting shape fixing ability at room temperature and shape recovery ability at body temperature. All scaffolds showed limited interaction with cells. The cell adhesion rate of PAA-PCL50 scaffold was 55%, the highest among the three scaffolds. To promote cellular adhesion, PAA-PCL50 scaffold was mineralized via in situ precipitation, exhibiting CaP particles on the inner surfaces. The mineralized scaffold still exhibited well-performed deformation and shape memory ability, with higher cell adhesion rate (86%) and proliferation rate. In vivo implantation result indicated that the mineralized PAA-PCL50 scaffold better supported tissue invasion, holding a great promise to improve neo-tissue formation.

Keywords:

• Shape memory scaffold
• poly (ε-caprolactone)
• CaP
• cellular adhesion
• tissue invasion
• minimally invasive implantation

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by The National Science Foundation for Young Scholars of China (Grant No. 81701422), and JINGCHEN Scientific Research Foundation (Grant No. JINGCHEN-SRF-2020001).