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ABSTRACT
Purpose: To highlight the rare but life-threatening infective consequences of immunosuppression or biologic treatment for sight-threatening uveitis.
Patients and methods: Retrospective case series of four immunosuppressed patients with uveitis complicated by sepsis.
Results: The affected patients were all treated using prednisolone 10 mg/day or greater, together with oral immunosuppression (2 mycophenolate mofetil, 1 azathioprine + ciclosporin, 1 methotrexate) and, in one case, infliximab. All patients survived following intensive treatment.
Conclusion: Life-threatening infection is a rare but important risk in immunosuppressed patients with uveitis. Complete protection is not possible and prophylaxis regimens are of unproven efficacy. Patients should understand the risks before agreeing to a course of treatment.
DECLARATION OF INTEREST
The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.
FUNDING
This research was facilitated by the Greater Manchester Local Clinical Research Network.