Multimodal Evaluation of Patients with Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Serpiginous Choroiditis

ABSTRACT

Purpose: To evaluate retinal and choroidal changes in patients with non-granulomatous choroiditis using the multimodality imaging (MMI).

Methods: Eight eyes of four patients were analyzed. Three patients (six eyes) were diagnosed with serpiginous choroiditis (SC) and one patient (two eyes) with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). The patients were imaged on the same day using the RTVue Avanti XR instrument OCT/OCTA (Optovue Inc, Fremont, CA), Heidelberg Retina Angiograph 2 FAF and FA (Heidelberg Engineering, Germany), and TRC50DXi Topcon FP (Topcon Medical Systems, Oakland, NJ).

Results: OCT angiography (OCTA) showed hypoperfusion in all the cases, reperfusion in choriocapillaris in two eyes after treatment and identified a choroidal neovascularization (CNV), which was not detected on the fluorescein angiography (FA).

Conclusions: OCTA may be an effective noninvasive image modality to follow up these patients and may provide further information to help us to understand the pathophysiology and complications of these diseases.

Keywords:

• Acute posterior multifocal placoid pigment epitheliopathy
• fluorescein angiography
• fundus autofluorescence
• optical coherence tomography angiography
• serpiginous choroiditis

Acknowledgments

This study was supported by the ophthalmology department of the Federal University of São Paulo (UNIFESP) and by the Instituto da Visão – IPEPO, São Paulo, Brazil.

Authorship

All authors attest that they meet the current ICMJE criteria for Authorship.

Declaration of interest

The authors declare that there are no conflicts of interest in relation to this article.