Systemic Moxifloxacin in Streptococcus viridans Endophthalmitis

ABSTRACT

Purpose: To evaluate the effectiveness of prophylactic systemic moxifloxacin in a rabbit model of Streptococcus viridans (S. viridans) endophthalmitis.

Methods: Animals (n=60) were divided into three groups. Intravenous moxifloxacin, vancomycin, normal saline was administered to 20 animals in each group and two hours later, 10⁴ colony-forming units (CFU) of S. salivarius were intravitreally injected into the left eye. Intravenous antibiotics injection was repeated on days 1, 2, and 3 after inoculation. The clinical features, bacterial culture from vitreous aspirates of 10 eyes from each group were evaluated on days 1, 3, 5, and 7. On day 7, eyes for clinical feature examination were enucleated for histopathologic examination.

Results: Clinical scores and log₁₀CFU/ml values were lower in moxifloxacin group on all examination days. Histopathologic examination showed less inflammation and relatively well-preserved retina in the moxifloxacin group.

Conclusions: Systemic moxifloxacin may have a prophyactic effect for S. viridans endophthalmitis after intraocular procedure.

Keywords:

• Intravitreal injection
• moxifloxacin
• postoperative endophthalmitis
• Streptococcus viridans

ACKNOWLEDGMENTS

Involved in design of study (K.Y.N., J.Y.K.); conduct of study (K.Y.N., J.Y.K.); collection of data (K.Y.N.); analysis and interpretation of data (K.Y.N., J.Y.K.); drafting of manuscript (K.Y.N.); and critical review of article (K.Y.N., S.J.L., J.Y.K.)..

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

ETHICS AND CONSENT TO PARTICIPATE

All of the animal experiments were approved by the Chungnam National University Hospital Animal Experiment Committee and the procedures were conducted according to the Association for Research in Vision and Ophthalmology Guidelines.

FUNDING

This study was supported by a grant from the Kosin University College of Medicine (2016), the Future Leading Research Supporting Program of Kosin University College of Medicine (2016), the University Research Park Project of Busan National University funded by the Busan Institute of S&T Evaluation and Planning, the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2017R1A2B400466).