The Impact and Implication of Peripheral Vascular Leakage on Ultra-Widefield Fluorescein Angiography in Uveitis

ABSTRACT

Purpose: To study if peripheral vascular leakage (PVL) on ultra-widefield fluorescein angiography (UWFFA) prognosticates complications of uveitis or necessitates treatment augmentation.

Methods: Retrospective cohort study of uveitis patients imaged with UWFFA and ≥1 yr of follow-up.

Results: We included 73 eyes of 42 patients with uveitis. There was no difference in baseline, intermediate, final visual acuity (p = 0.47–0.95) or rates of cystoid macular edema (CME) (p = 0.37–0.87) in eyes with PVL vs. those without. Eyes with PVL receiving baseline treatment augmentation were more likely to have baseline CME but were not more likely to have impaired visual acuity at final follow-up. PVL was independently associated with treatment augmentation on generalized estimating equation analysis with multivariable linear regression (OR: 4.39, p = 0.015).

Conclusions: PVL did not confer an increased risk of impaired VA or CME at ≥1 yr follow-up but was possibly an independent driver of treatment augmentation.

Keywords:

• Fluorescein angiography
• macular edema
• peripheral vascular leakage
• uveitis
• widefield imaging

DECLARATION OF INTEREST

JTR is a consultant for Abbvie, UCB, Gilead, Genentech, Janssen, Santen, Novartis, Cavtherx, Portage, Mitotech, Digital Theraeutics, Xoma, Theravance

EBS is a consultant for Abbvie, Mallinckrodt, Santen, and XOMA and currently receives or has received research support from Abbvie, Bristol Meyers Squibb, Clearside, EyeGate, Genentech, pSivida, and the National Institute of Health.

FUNDING

This work was supported by the National Eye Institute [K08EY022948] [PL]; National Institutes of Health [P30 EY10572]; Research to Prevent Blindness [Individual Career Development Award (PL),Unrestricted institutional grant];

Additional information

Funding

This work was supported by the National Eye Institute [K08EY022948];NIH [P30 EY010572];Research to Prevent Blindness [Individual Career Development Award,Unrestricted institutional grant];