The Role of Dexamethasone Implant in the Management of Tubercular Uveitis

ABSTRACT

Purpose: To study the safety and efficacy of intravitreal injection of dexamethasone implant in the management of posterior segment involvement in tubercular uveitis (TBU).

Methods: In this study, retrospective analysis of safety and efficacy of intravitreal injection of dexamethasone implant for various indications such as cystoid macular edema (CME), vitritis, or paradoxical worsening in TB-related intermediate uveitis, retinal vasculitis, and multifocal serpiginoid choroiditis (MSC) was performed.

Results: The study included 17 patients (19 eyes; 7 males). IOP increased from 14.88 ± 2.68 mm Hg to 16.4 ± 5.82 mm Hg (p = 0.18) at 3 months. BCVA improved from 0.37 ± 0.35 to 0.27 ± 0.21 at 3 months (p = 0.03). CME resolved at 3 months and two patients with paradoxical worsening showed resolution within 1 month.

Conclusion: Intravitreal dexamethasone implant is safe and efficacious as an adjunct to ATT in reducing the central macular thickness, vitritis, and progression of choroiditis lesions in paradoxical worsening of MSC.

Keywords:

• Cystoid Macular Edema
• Dexamethasone Implant
• Intraocular Tuberculosis
• Ozurdex
• Retinal Vasculitis
• Serpiginous Choroiditis
• TB

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

FUNDING

This work was partly supported by a grant from Department of Biotechnology (DBT), India for the development of Centre of Excellence at the Advanced Eye Centre, PGIMER Chandigarh.

Additional information

Funding

This work was partly supported by a grant from Department of Biotechnology (DBT), India for the development of Centre of Excellence at the Advanced Eye Centre, PGIMER Chandigarh.