Endogenous Fungal Endophthalmitis Associated with Genitourinary Procedures

ABSTRACT

Purpose: To summarize the characteristics of endogenous fungal endophthalmitis (EFE) after genitourinary procedures.

Methods: Medical records of patients diagnosed with EFE after genitourinary procedures from a single center during a 6-year period were reviewed.

Results: Nineteen eyes of 15 patients were included. The interval time between procedure to symptom was 3.6 ± 3.6 weeks. As the initial treatment, 9/19 eyes underwent primary vitrectomy and 10/19 eyes underwent intravitreal antifungal injection . Candida albicans was the pathogen in 15 of 19 eyes. Systemic treatment with itraconazole was used in all patients. LogMAR best corrected visual acuity improved from 2.2 ± 0.9 to 0.9 ± 1.2 after treatment (p = 0.002) in 15 eyes that were followed-up for an average of 4.9 ± 2.1 years.

Conclusion: Genitourinary procedure is a predisposing factor for EFE. Candida albicans is the predominant pathogen. Normative systemic and local antifungal treatments improved the final visual outcome.

Keywords:

• Causative organism
• endogenous
• fungal endophthalmitis
• genitourinary procedure
• predisposing risk factors

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This work was supported by National Natural Science Foundation of China (81570854), National Key Basic Research Program of China (2013CB967503), Grant from Science and Technology Commission of Shanghai Municipality (16411953700), and Grant from Shanghai Hospital Development Center (SHDC12016116).