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ABSTRACT
Purpose: To investigate the prevalence of macular abnormalities in Chinese Vogt-Koyanagi-Harada (VKH) patients.
Methods: Clinical characteristics, therapeutic effectiveness and visual outcome were reviewed and analyzed.
Results: The most common macular abnormality was macular edema (ME), followed by macular choroidal neovascularization (CNV). Macular abnormalities were associated with recurrent episodes, disease course and visual acuity ≤20/50 at first visit. The prevalence of macular abnormalities in patients who were not treated according to our regular treatment regimen with corticosteroids combined with immunosuppressive agents and who were followed-up for at least one year (13.1%) was significantly higher than in patients receiving the regular treatment (5.7%). Visual improvement was found in 66.7% of eyes with macular abnormalities after regular treatment.
Conclusion: Macular abnormalities were associated with recurrent uveitis, course of disease and lower visual acuity at first visit. Regular treatment could prevent the development of macular abnormalities and improved visual outcome in most patients.
Acknowledgments
This work was supported by Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003), Innovation project of Chongqing Science & Technology commission (cstc2017shmsA130073), Key Project of Health Bureau of Chongqing (2012-1-003) and Chongqing Science & Technology Platform and Base Construction Program (cstc2014pt-sy10002).
We thank all the patients who participated in this study.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Supplemental material
Supplementary data for this article can be accessed here