In Vivo Analysis and Comparison of Anterior Segment Structures of Both Eyes in Unilateral Herpetic Anterior Uveitis

ABSTRACT

Purpose: To compare the Schlemm’s canal area (SCA) and to define iris features in patients with unilateral herpetic anterior uveitis (HAU) by using anterior segment spectral-domain optical coherence tomography (AS SD-OCT).

Methods: Unilateral HAU cases that had been in complete remission for ≥ 3 months were included. Two investigators analyzed the iris features of HAU. SCA in both healthy (N), and affected eyes (HAU) were compared.

Results: The mean age of the participants (n = 22) was 36.3 ± 15 (17–70) years. The mean nasal and temporal (n-t) SCA was measured as 10,844 ± 4806 µm² and 8,772 ± 3138 µm² in HAU in comparison with 10,200 ± 4,824 µm² and 10,045 ± 3,889 µm² in N, respectively (p = .47 and p = .12, respectively). The most common iris features were the sectoral iridoplegia (100%) on biomicroscopy and the disorganization of the iris layers (DIL) (77%) on AS SD-OCT images.

Conclusion: SCA found similar on both sides. DIL is the most common iris feature of affected eyes.

KEYWORDS:

• Herpetic anterior uveitis
• Schlemm’s canal
• anterior segment spectral-domain optical coherence tomography

Authors’ Contributions

M.D.O, F.K. performed the data collection, M.D.O. was involved in planning and supervised the work, M.D.O, F.K, M.B, E.S, S.T processed the experimental data, performed the analysis, drafted the manuscript and designed the figures. All authors discussed the results and commented on the manuscript.

Declaration of interest

Author Muhammet Derda OZER declares that he has no conflicts of interest. Author Erbil SEVEN declares that he has no conflicts of interest. Author Serek TEKIN declares that he has no conflicts of interest, Author Fatih KEBAPCI declares that he has no conflicts of interest. Author Muhammed BATUR declares that he has no conflicts of interest.

Availability of Data and Materials

The data supporting our findings can be found at Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Ophthalmology Department, Uveitis section secretary (Muhammet Ozer [2020], “In Vivo Analysis and Comparison of Anterior Segment Structures of Both Eyes in Unilateral Herpetic Anterior Uveitis”, Mendeley Data, V2, doi: 110.17632/hmz2cz3jcg.2).

Consent to Publish

Written informed consent for publication was obtained from all of the participants.

Ethics Approval and Consent to Participate

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by Van Yuzuncu Yil University, Dursun Odabas Faculty of Medicine, Surgical and Pharmaceutical Research Ethics Board.

Additional information

Funding

No commercial relationship exists for any of this article’s authors in the form of financial support or personal financial interest.