Dexamethasone Intravitreal Implant (Ozurdex) in Paediatric Patients with Non-infectious Intermediate Uveitis and Related Cystoid Macular Oedema: Evaluation of Macular Morphology and Function with Six-month Follow-up; a Deeper Role of MfERG?

ABSTRACT

Purpose

To evaluate the efficacy of Ozurdex implant by analyzing macular morphology and function in pediatric uveitis and related cystoid macular edema (CMO).

Methods

Main outcomes were visual acuity, mfERG and photopic ERG response, and central macular thickness. Mean values recorded at each time-point were compared to baseline and correlations between functional and anatomical parameters were evaluated.

Results

Resolution of intraocular inflammation and CMO was achieved in all eyes 1 month after implant without procedure or drug-related complications. Mean visual acuity and mfERG amplitude improved showing a statistically significant difference to baseline values for the first 4 months. Mean central macular thickness showed a statistically significant reduction for all follow-up time. Photopic ERG did not vary significantly. Statistically significant correlation was found between trends of visual acuity, central macular thickness, and mfERG responses.

Conclusion

Correlation found between macular morphology and function confirms the efficacy of Ozurdex in pediatric uveitis.

KEYWORDS:

• Noninfectious intermediate uveitis
• cystoid macular edema (CMO)
• dexamethasone intravitreal implant (Ozurdex)
• macular function
• mfERG

Declaration of Interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.