A Novel Method of Quantifying the Choriocapillaris in Normal and Post-inflammatory Eyes

ABSTRACT

Objective

To assess the reliability and validity of gray level co-occurrence matrices (GLCM) in the quantification of choriocapillaris and describe GLCM features in normal and eyes with resolved acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and serpiginous choroiditis (SC).

Methods

In this, multicenter, reliability, validity and comparative study; OCTA was performed on eyes with resolved APMPPE and SC and normal individuals. CC texture classification, low flow area measurements and GLCM feature extraction were performed.

Results

A total of 13 normal, 8 APMPPE and 15 SC eyes were analyzed. All GLCM parameters demonstrated an excellent reliability. GLCM parameters were differently distributed across the three groups. Decision-tree based on the random forest predictive model provided an overall accuracy of 86% in classifying the three groups using GLCM features.

Conclusion

These data demonstrated an excellent reliability and validity of GLCM features in quantifying the choriocapillaris in healthy and diseased eyes.

KEYWORDS:

• Acute posterior multifocal placoid pigment epitheliopathy
• choriocapillaris
• choroiditis
• optical coherence tomography angiography
• primary inflammatory choriocapillaropathies
• quantitative analysis of choriocapillaris
• serpiginous choroiditis
• Uveitis

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.