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Invited Review

Allergy and Dry Eye Disease

, MDORCID Icon, , MD & , MD
Pages 1168-1176 | Received 26 Jul 2020, Accepted 20 Oct 2020, Published online: 05 Feb 2021
 

ABSTRACT

Ocular allergy (OA) and dry eye disease (DED) are the most common ocular surface disorders with a potential severe impact on the patient’s quality of life. OA and DED may coexist and have a significant clinical overlap. Therefore, clinical features commonly believed to be distinctive of OA or DED may be sometimes insufficient for a differential diagnosis. Alterations of the tear film, epithelial barrier, and corneal innervation are described in OA and can pave the way to DED. Conversely, DED may facilitate or worsen allergic reactions in predisposed (atopic) patients. For these reasons, OA and DED should be considered as reciprocal predisposing conditions that share ocular surface inflammation as a common background.

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Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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