Chorioretinal Atrophy in Punctate Inner Choroidopathy/multifocal Choroiditis: A Five-year Follow-up Study

ABSTRACT

Purpose

To report the 5-year results of chorioretinal atrophy (CRA) progression in patients with punctate inner choroidopathy (PIC) or multifocal choroiditis (MFC).

Methods

A retrospective study included PIC/MFC patients with secondary CRA formation. The area of CRA was measured and the progression rate was calculated. Multiple regression analysis was performed to investigate risk factors associated with CRA progression.

Results

Forty-five eyes of 36 patients were included. The mean CRA size significantly increased after an average of 4.83 years of follow-up with progression rate of 0.69 mm²/year. Moreover, we had identified the axial length and initial PIC lesion number as significant risk factors for CRA progression.

Conclusion

Significant CRA enlargement is noted in PIC/MFC patients after 5 years of follow-up. The progression rate is associated with axial length and initial PIC numbers. Aggressive treatment is suggested for eyes with more initial lesion numbers and longer axial length to control the faster CRA progression.

KEYWORDS:

• Chorioretinal atrophy
• punctate inner choroidopathy
• multifocal choroiditis
• long-term outcome
• white dots syndrome

Acknowledgments

The authors would like to thank Ie-Bin Lian, Professor from Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua, Taiwan, for his assistance with the statistical analyses.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.