Granulocyte Colony Stimulating Factor-induced Immune Recovery Uveitis Associated with Cytomegalovirus Retinitis in the Setting of Good Syndrome

ABSTRACT

Purpose

To report a case of immune recovery uveitis (IRU) secondary to cytomegalovirus (CMV) retinitis in a patient with Good syndrome treated with granulocyte colony stimulating factor (GCSF).

Methods

A case report.

Case

A 54-year-old woman with a history of Good syndrome for 2 years presented with chronic panuveitis in her right eye for 6 months. She had received multiple doses of GCSF for a pulmonary infection. Her visual acuity was hand movement in the right eye. Few anterior chamber cells, dense vitreous haze, and chorioretinal lesions were noted. Granular retinal atrophic lesions without obvious infiltration were observed during diagnostic vitrectomy. Polymerase chain reaction of the vitreous sample was positive for CMV DNA. A diagnosis of IRU secondary to CMV retinitis was made. The inflammation was controlled with topical steroids after surgery.

Summary

In this report, we present a patient with Good syndrome who developed IRU secondary to CMV retinitis.

KEYWORDS:

• Cytomegalovirus
• good syndrome
• granulocyte colony stimulating factor
• immune recovery uveitis
• thymoma

Declaration of interest

The authors declare no competing interests.

Additional information

Funding

This research did not receive any specific funding.