Hodgkin Lymphoma Associated Retinopathy: Report of a Case

ABSTRACT

Purpose

To report a case of Hodgkin lymphoma (HL) associated retinopathy.

Method

Single-case, retrospective review of ophthalmological and systemic manifestations.

Results

A bilateral panuveitis in a 17-year-old Caucasian woman led to the diagnosis of HL. The ocular findings were characterized by anterior uveitis, vitritis, white chorioretinal lesions, papillitis and vasculitis. The diagnosis of nodular sclerosis stage IIA HL was confirmed by a cervical ganglion biopsy. Other causes of uveitis were excluded. The remission of HL was obtained by chemotherapy and the ocular lesions became quiescent, with pigmented chorioretinal scars, predominating along retinal vessels. Recurring visual symptoms one year later led to the diagnosis of the relapse of the HL. The remission of the HL was again obtained by a second line of chemotherapy while ocular symptoms subsided.

Conclusions

Hodgkin lymphoma may be added to the list of diseases that can occasionally be revealed by ocular paraneoplastic syndromes.

KEYWORDS:

• Posterior uveitis
• white chorioretinal lesions
• Hodgkin lymphoma
• ocular paraneoplastic syndrome
• autoimmune retinopathies

Declaration of interest

All authors report no conflict of interest.

Additional information

Funding

This case study was approved by the Ethics Committee of the French Society of Ophtalmology [IRB 00008855 Société Française d’Ophtalmologie IRB#1].