A Case of Spontaneous Regression and Recurrence of Primary Vitreoretinal Lymphoma

ABSTRACT

Purpose

To report a case of primary vitreoretinal lymphoma (PVRL) showing recurrence after spontaneous regression, diagnosed with the aid of next-generation sequencing (NGS).

Methods

Retrospective case report.

Results

A 61-year-old immunocompetent Korean woman presented with subretinal lesions suspected of PVRL, which resolved spontaneously in 2 months. After 8 months, the lesion recurred and diagnostic vitrectomy was performed. The cytologic examination of the vitreous was indeterminate as there was only minimal vitreous opacity present at the time of surgery. NGS identified significant mutations including single nucleotide variants in MYD88 L265P, which is a unique hallmark of VRL, in vitreous sample, and the diagnosis of PVRL was made.

Conclusion

This case showed PVRL can spontaneously regress almost completely, then recur, so careful ophthalmic and systemic follow-ups are warranted. When cytological confirmation is challenging due to the minimal disease involvement in the vitreous, NGS is effective in confirming the mutation profiles of PVRL.

KEYWORDS:

• Vitreoretinal lymphoma
• intraocular lymphoma
• next-generation sequencing
• MYD88 L265P mutation

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Additional information

Funding

This research was supported by the Basic Science Research Program through theNational Research Foundation of Korea (NRF) under Grant 2019R1A2C2002393 (C.S.L.).