Association of miRNA-146a Gene Polymorphism Rs2910164 with Behcet’s Disease: A Meta-analysis

ABSTRACT

Background

A meta-analysis was performed by summarizing relevant researches to evaluate the relationship between miRNA-146a gene polymorphism rs2910164 and Behcet’s disease (BD).

Methods

A systematic search of published studies was conducted in PubMed and Embase. Five eligible studies involving 1167 BD cases and 1662 controls were included in the current meta-analysis.

Results

The results suggested that the polymorphism rs2910164 was correlated with BD susceptibility in all genetic models. In subgroup analysis according to ethnicity, the relationship between this polymorphism and BD was more significant in Caucasians (allele model: OR = 0.49, 95% CI 0.39–0.61; heterozygote model: OR = 0.35, 95% CI 0.26–0.47; homozygote model: OR = 0.29, 95% CI 0.16–0.53; dominant model: OR = 0.34, 95% CI 0.25–0.45; recessive model: OR = 0.56, 95% CI 0.50–0.72) than that in Asians.

Conclusion

In conclusion, this meta-analysis indicates that miRNA-146a gene polymorphism rs2910164 G allele confers BD susceptibility, especially in Caucasians.

KEYWORDS:

• Polymorphism
• MiR-146a
• Rs2910164
• meta-analysis
• Behcet’s disease

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Ethical approval

This article does not include any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.

Additional information

Funding

This work was supported by National Natural Science Foundation of China [81770914, 81970792 and 81800832] and Medical Science and Technology Project of Health Commission of Henan Province [YXKC2020026].