ABSTRACT
Purpose
To evaluate complete blood count (CBC)-derived inflammatory indices in central retinal artery occlusion (CRAO).
Methods
A total of 42 patients with CRAO (CRAO group) and 42 age- and sex-matched subjects without CRAO (Control group) were included. CBC parameters including red cell distribution width (RDW) levels were assayed. Platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and neutrophil/ lymphocyte ratio (NLR) were calculated.
Results
RDW, PLR, SII and NLR values were significantly higher in CRAO group than control group [15.2 ± 1.47% vs 13.96 ± 1.13% (p < .001), 127.94 ± 48.21 vs 101.16 ± 24.84 (p = .008), 667.11 ± 357.84 vs 493.44 ± 207.07 (p = .008), 2.70 ± 1.27 vs 2.13 ± 0.83 (p = .018), respectively]. In multivariate analysis only RDW was independent predictor for CRAO (OR 2.317, p < .001). On ROC analysis, area under curve of RDW, PLR, SII, and NLR for CRAO were 0.761, 0.685, 0.622 and 0.618, respectively.
Conclusion
RDW seems superior to other inflammatory indices to predict CRAO.
Contributions
AE, BEK—conception or design of the work; the acquisition, analysis, interpretation of datas, AE, BEK, DOO—drafted the work or revised it critically for important intellectual content.
AE, BEK, SCO, ED—Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
AE (Ahmet Elbeyli), BEK (Bengi Ece Kurtul), DOO (Deniz Ozarslan Ozcan), SCO (Sait Coskun Ozcan), ED (Emine Dogan)
Data availability
All data are included in this paper.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
This article does not contain any studies with animals performed by any of the authors.
All authors approved the version to be published.
Informed consent
Informed consent was obtained from all individual participants included into the study.