Intraocular Metastasis of Large T-cell Lymphoma Transformed from Mycosis Fungoides

ABSTRACT

Purpose

To describe a rare case of intraocular lymphoma that metastasized from cutaneous mycosis fungoides and transformed to large cell T cell lymphoma resulting in vitreoretinal pathology.

Methods

Retrospective case report.

Results

A 57-year-old male presented with 3 months of blurred vision in the right eye. He reported only a medical history of psoriasis. Examination revealed keratic precipitates and dense vitritis in the right eye. He was taken for a diagnostic vitrectomy. Histopathology showed that atypical lymphoid cells and flow cytometry were consistent with transformed large cell T-cell lymphoma. During follow-up, pre- and inner retinal lesions were noted throughout the posterior pole. Histopathology of the psoriatic lesions was consistent with mycosis fungoides. He was initiated on systemic and intravitreal methotrexate with improvement in vision.

Conclusions

Ocular involvement in metastatic transformed T-cell lymphoma is extremely rare but can be present with vitritis and retinal deposits. Our patient responded well to intravitreal methotrexate therapy.

KEYWORDS:

• Intraocular lymphoma
• mycosis fungoides
• T cell lymphoma
• uveitis
• vitritis

Author’s contributions

David Sarraf: Consultant for Amgen, Bayer Healthcare, Genentech, Novartis, and Optovue and receives research or financial support from Allergan, Genentech, Heidelberg, Optovue, and Regeneron (Tarrytown, New York)

Brian Marr: Consultant for Aura Biosciences

Yasha Modi: Consultant to Alimera, Allergan, Thea, and Zeiss

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.