Paracentral Acute Middle Maculopathy in A Young Girl Treated with Interferon-Beta for Nasopharyngeal Carcinoma

ABSTRACT

Purpose

To describe a case of interferon-beta retinopathy associated with paracentral acute middle maculopathy

Case report

A 15-year-old girl with Epstein–Barr virus-positive advanced nasopharyngeal carcinoma WAS REFERRED with reduced visual acuity. Multimodal imaging findings, including optical coherence tomography angiography, at presentation and evolution following cessation of interferon therapy are presented.

Conclusion

The presentation of paracentral acute middle maculopathy in this patient supports the presumed ischaemic pathogenesis in interferon retinopathy. The imaging findings provide evidence of deep capillary plexus involvement in interferon retinopathy with evolution to permanent structural damage within the inner nuclear layer.

KEYWORDS:

• Interferon-beta
• multimodal imaging
• optical coherence tomography
• optical coherence tomography angiography
• paracentral acute middle maculopathy

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.