Assessment of Systemic Immune-inflammation Index Levels in Patients with Retinal Vein Occlusion

ABSTRACT

Purpose

To assess the predictive value of inflammatory markers calculated from complete blood counts in patients with retinal vein occlusion (RVO).

Methods

This was a retrospective cross-sectional study with a total of 56 RVO patients and 56 age- and gender-matched controls involved. All subjects went through a routine ocular examination, and the peripheral venous blood samples were collected to analyze the differences in inflammatory markers between groups.

Results

The systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) values were significantly higher in RVO patients than those in the controls (p=0.002, p=0.004, respectively). According to the receiver operating characteristic (ROC) curve analysis, the areas under the curve (AUC) of SII was 0.666. The AUC of NLR was 0.657.

Conclusion

As a novel inflammatory indicator, SII is a more promising indicator than NLR and PLR in the prediction of RVO development.

KEYWORDS:

• Systemic immune-inflammation index
• complete blood count
• retinal vein occlusion
• neutrophil-to-lymphocyte ratio
• platelet-to-lymphocyte ratio

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability

The data used to support the findings of this study are available on request from the corresponding author.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.