ABSTRACT
Purpose
To compare the differences in peripheral blood inflammatory indices between patients with neovascular age-related macular degeneration (nAMD) and haemorrhagic polypoidal choroidal vasculopathy (PCV).
Methods
Retrospective, best corrected visual acuity (BCVA), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR), were analysed across the nAMD, PCV and normal control (NCG) groups of patients. The ratios’ cut-off values for nAMD were calculated.
Results
nAMD had a significantly longer duration and better BCVA than PCV (all P < .05). The NLR, MLR and PLR were significantly higher in nAMD than in PCV and NCG (all P < .01), no significant differences between PCV and NCG (all P > .05). The ROC curve analysis revealed that the cut-off values for NLR and MLR were 1.98 and 0.24, respectively, for nAMD.
Conclusion
NLR, MLR and PLR are significantly high in patients with nAMD. The ability of these inflammatory indicators to distinguish nAMD and PCV is unclear.
Acknowledgments
Approval of the Institutional Review Board (IRB). The study was approved by the First Affiliated Hospital of Hainan Medical University.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Author contributions
All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Weiwen Hu, Yikeng Huang and Xionggao Huang. The first draft of the manuscript was written by Weiwen Hu and Yikeng Huang. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Hainan Medical University on 2021/030.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Consent to publish
All authors declared their consent to the publication of the manuscript.