The Vitreous in Uveitis: Characterizing the Invisible with Optical Coherence Tomography

ABSTRACT

Purpose

The current gold standard to grade vitreous inflammation is the Nussenblatt scale based in clinical examination, published in 1985. Nowadays a big effort is undergoing to come out with more objective and reliable methods based in optical coherence (OCT) imaging analysis.

Methods

A systematic review was done to identify the articles that quantify or assess qualitatively vitreous inflammation with OCT.

Results

Twelve papers were included. Only one paper analyzed qualitatively the anatomy of the vitreous body and its potential influence in cystoid macular edema, while the rest assessed vitreous inflammation quantitatively using the relative reflectivity of the vitreous body with different retinal structures or quantifying the hyperreflective dots in the vitreous.

Conclusion

The new development of OCT-based scales for measuring vitreous inflammation could replace the current clinical grading scales as an end point for future clinical trials.

KEYWORDS:

• OCT
• uveitis
• VIT/RPE
• vitreous haze
• vitritis

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.