A Case of Sterile Corneal Stromal Infiltration with Hypotonic Maculopathy Under Brimonidine Treatment

ABSTRACT

Introduction

Brimonidine is a commonly used drug for glaucoma treatment, which has been linked to ocular autoimmune disorders like uveitis and conjunctivitis. Corneal pathology under brimonidine is generally less common.

Case description

Here, we report a 78 -year-old male patient suffering from immune corneal stromal inflammation with hypotony and resulting hypotonic maculopathy after 6 weeks after introduction of brimonidine treatment. Systemic work-up for system autoimmune and infectious diseases was negative. We discontinued brimonidine and administered topical prednisolone under which inflammatory corneal signs and intraocular pressure normalized. Chorioretinal folds persisted after 9 months.

Conclusion

Our case report suggests monitoring patients under brimonidine for sterile corneal infiltration.

KEYWORDS:

• AS-OCT
• Brimonidine
• corneal stromal inflammation
• hypotonic maculopathy
• ocular hypotony

Patient consent

Written informed consent for patient information and images to be published was provided by the patient.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) received no financial support for the research, authorship and/or publication of this article.