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Ocular Immunology and Inflammation Volume 31, 2023 - Issue 7
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Original Articles

Risk Factors for Legal Blindness in 77 Japanese Patients with Endogenous Endophthalmitis: A Multicenter Cohort Study from J-CREST

Takaaki Sugisawaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;b Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, JapanView further author information
, MD,
Hiroto Ishikawaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;b Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan;c Department of Ophthalmology, Mirai Eye & Skin Clinic, Osaka, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0760-7203View further author information
, MD, PhDORCID Icon,
Kazutaka Uchidad Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, JapanView further author information
, MD, PhD,
Yoshio Takesuee Department of Infection Control and Prevention, Hyogo College of Medicine, Nishinomiya, JapanView further author information
, MD, PhD,
Junya Moria J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;f Department of Ophthalmology, Sapporo City General Hospital, Sapporo, JapanView further author information
, MD,
Takamasa Kinoshitaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;f Department of Ophthalmology, Sapporo City General Hospital, Sapporo, JapanORCID Iconhttps://orcid.org/0000-0002-0465-2140View further author information
, MD, PhDORCID Icon,
Shohei Morikawaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;g Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanView further author information
, MD, PhD,
Fumiki Okamotoa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;g Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanView further author information
, MD, PhD,
Tomoko Sawadaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;h Department of Ophthalmology, Shiga University of Medical Science, Otsu, JapanView further author information
, MD, PhD,
Masahito Ohjia J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;h Department of Ophthalmology, Shiga University of Medical Science, Otsu, JapanView further author information
, MD, PhD,
Takayuki Kandaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;i Department of Ophthalmology, National Defense Medical College, Tokorozawa, JapanView further author information
, MD,
Masaru Takeuchia J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;i Department of Ophthalmology, National Defense Medical College, Tokorozawa, JapanView further author information
, MD, PhD,
Akiko Mikia J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;j Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, JapanView further author information
, MD, PhD,
Sentaro Kusuharaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;j Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, JapanView further author information
, MD, PhD,
Tetsuo Uedaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;k Department of Ophthalmology, Nara Medical University School of Medicine, Kashihara, JapanView further author information
, MD,
Nahoko Ogataa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;k Department of Ophthalmology, Nara Medical University School of Medicine, Kashihara, JapanView further author information
, MD, PhD,
Masahiko Sugimotoa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;l Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, JapanView further author information
, MD, PhD,
Mineo Kondoa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;l Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, JapanView further author information
, MD, PhD,
Shigeo Yoshidaa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;m Department of Ophthalmology, Kurume University School of Medicine, Kurume, JapanView further author information
, MD, PhD,
Tadahiko Ogataa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;n Department of Ophthalmology, Graduate School of Medicine, Yamaguchi University, Ube, JapanView further author information
, MD,
Kazuhiro Kimuraa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;n Department of Ophthalmology, Graduate School of Medicine, Yamaguchi University, Ube, JapanView further author information
, MD, PhD,
Yoshinori Mitamuraa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;o Department of Ophthalmology, Tokushima University Graduate School, Tokushima, JapanView further author information
, MD, PhD,
Tatsuya Jujoa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;p Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, JapanView further author information
, MD,
Hitoshi Takagia J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;p Department of Ophthalmology, St. Marianna University School of Medicine, Kawasaki, JapanView further author information
, MD, PhD,
Hiroto Terasakia J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;q Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanView further author information
, MD, PhD,
Taiji Sakamotoa J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;q Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanView further author information
, MD, PhD,
Yuki Komukua J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;b Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, JapanView further author information
, MD, PhD &
Fumi Gomia J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan;b Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, JapanView further author information
, MD, PhD show all
Pages 1505-1512 | Received 15 Mar 2022, Accepted 14 Jul 2022, Published online: 25 Aug 2022
 
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ABSTRACT

Purpose

We investigated potential predictive factors for visual prognosis in Japanese patients with endogenous endophthalmitis.

Design

Retrospective observational multicenter cohort study.

Methods

We examined the characteristics of 77 Japanese patients with endogenous endophthalmitis and performed statistical analyses of these real-world data. The primary endpoint was the identification of factors associated with visual prognosis. We examined differences between patients in the better vision and legal blindness groups at 12 weeks after treatment initiation.

Results

The five risk factors for visual impairment at 12 weeks after treatment initiation were presence of pressure injuries, severe clinical symptoms (presence of eye pain and ciliary injection), pathogen identification, and poor best-corrected visual acuity at baseline. Staphylococcus aureus and fungus were associated with a better visual impairment outcome.

Conclusions

Endogenous endophthalmitis remains a severe ocular infection; however, it can be managed with rapid treatments, as well as other advances in medical knowledge and technology.

Acknowledgments

We thank Ryan Chastain-Gross, Ph.D., from Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article or its supplementary materials.

SUPPLEMENTARY MATERIAL

Supplemental data for this article can be accessed online at https://doi.org/10.1080/09273948.2022.2112237

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.

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