ABSTRACT
Purpose
To compare the utility of the Chinese diagnostic criteria for Vogt–Koyanagi–Harada (VKH) disease (CDCV), the revised diagnostic criteria (RDC) and the classification criteria by SUN (SUN-C).
Methods
Two groups of patients (VKH group and non-VKH group) were assessed in this retrospective case–control study. Sensitivity, specificity and area under receiver operating characteristic curve (AUC) were evaluated among these criteria.
Results
258 patients were included after propensity score matching. The sensitivities were 92.2% in CDCV, 66.7% in RDC, and 54.3% in SUN-C. In different disease stages (early and late), similar sensitivity results were observed. The specificities were 96.1% in CDCV, 97.7% in RDC, and 99.2% in SUN-C. The AUCs were 0.942 in CDCV, 0.822 in RDC and 0.767 in SUN-C.
Conclusion
A higher sensitivity value and larger AUC in CDCV were found. CDCV are highly useful in the diagnosis and classification of VKH disease in Chinese patients.
List of abbreviations
VKH, Vogt–Koyanagi–Harada; AUS, American Uveitis Society; RDC, the revised diagnostic criteria; CDCV, the Chinese diagnostic criteria of VKH disease; SUN, Standardization of Uveitis Nomenclature; SUN-C, the classification criteria for VKH disease by SUN; CSF, cerebrospinal fluid; FFA, fluorescein fundus angiography; OCT, optical coherence tomography; PSM, propensity score matching; AUCs, areas under receiver operating characteristic curves; WMU, Wenzhou Medical University; ICGA, indocyanine green fluorescein angiography; UBM, ultrasound biomicroscope; SD-OCT, spectral domain OCT; EDI, enhanced depth imaging; FAF, fundus autofluorescence; OCTA, optical coherence tomography angiography; RPE, retinal pigment epithelium; BDUMP, bilateral diffuse uveal melanocytic proliferation
Acknowledgments
We would like to thank Miss Wanyun Zhang from the First Affiliated Hospital of Chongqing Medical University, Chongqing, China for her suggestions on writing the original manuscript.
Author contributions
YW and JW conceived and conducted this study. JW and SP searched the literature. JW and RL recruited patients and collected related demographics, clinical features and results of examinations. JW, XG and WP analyzed and interpreted the data. YW, DL and MD determined the diagnosis of all involved patients. JW wrote the initial draft of the paper. YW supervised this research. All authors provided a final review and approved the manuscript before submission.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Ethics approval and consent to participate
The study followed the principles of the Declaration of Helsinki and was approved by the ethics committee of the Eye Hospital of Wenzhou Medical University (2019–015–K–15). This study was granted an exemption from informed consent.
Data availability statement
The datasets used during the current study are available from the corresponding author on reasonable request by email at [email protected].