Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Rare Presentation of Anklylosing Spondylitis or a Paradoxical Reaction to Secukinumab?

ABSTRACT

Purpose

To describe an atypical presentation of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in a patient with ankylosing spondylitis (AS) receiving secukinumab.

Methods

Retrospective chart review.

Results

A 48-year-old female patient with AS receiving secukinumab complained of impaired vision in her left eye. Left eye examination revealed multiple yellow-white lesions at the posterior pole and central subfoveal fluid.The lesions regressed without scarring. The case was diagnosed with clinically APMPPE.

Conclusion

In AS patients, posterior uveitis can manifest as APMPPE. It should be recorded as an entity to be considered in the differential diagnosis.

KEYWORDS:

• Ankylosing spondylitis
• APMPPE
• inflammatory chorioretinopathies
• posterior uveitis
• secukinumab

Disclosure statement

No potential conflict of interest was reported by the authors.

Authors’ contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by [Yeliz Delibay], [Mustafa Erdogan] and [Muhammed Altinisik]. The first draft of the manuscript was written by [Muhammed Altinisik] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.