https://orcid.org/0000-0003-3753-1035
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ABSTRACT
Objective
In this study, we investigated the impact of the SARS-CoV-2 vaccination on seroprevalence in a cohort of healthcare workers (HCW) at an ophthalmic medical center.
Methods
IgG antibodies against the N, S1, and S2 antigens of SARS-CoV-2 as well as their serum neutralizing activity were determined.
Results
In the present study, we observed that 98.4% of HCW were seropositive for S1/S2 proteins of SARS-CoV-2 due to the national vaccination program. Interestingly, 78.4% of the participants had anti-N protein antibodies, suggesting previous COVID-19 infection. We also evaluated the neutralizing antibodies and found that the mean value was high (90.7%).
Conclusion
These results indicate that our HCWs cohort presented a robust hybrid humoral response owing to the massive national vaccination program and natural infections.
Acknowledgments
Financial support: J.H. received a grant support from the Consejo Nacional de Ciencia y Tecnología (CONACyT; 314320).
Disclosure statement
No potential conflict of interest was reported by the author(s).
Author contributions
Conceptualization: Y.G.B. and J.H.; formal analysis, V.A.V.G., F.S.M.G., B.B.V., I.I.C., P.J.S.C., J.E.A.F., V.A.V.G.; resources, Y.G.B., J.H., J.E.M.M, and V.M.H.; data curation, Y.G.B., A.G.S.L., J.E.M.M.; writing—original draft preparation, Y.G.B.; writing—review and editing, Y.G.B., A.G.S.L., J.E.M.M., V.M.H, and J.H.; funding acquisition, Y.G.B., and J.H. All authors have read and agreed to the published version of the manuscript.
Financial support
CONACYT project number 314320 and DGAPA-PAPIIT project number IN203821.