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Abstract
The purpose of the article is to investigate the diurnal variation of intraocular pressure (IOP) in glaucoma patients by periodic regression analyses using two-way analysis of variance (ANOVA). Seventy-two open-angle glaucoma patients participated in this study and IOP measurements were taken in this group every 2 h during waking hours. Patients were categorized based on the Glaucoma staging system (GSS) into “severe” (GSS > stage 2) and “less severe” (GSS ≤ stage 2) groups. They were also categorized into high tension (IOP ≥ 19 mmHg) and low tension (IOP < 19 mmHg) groups. Diurnal IOP curves were plotted and analyzed for all patients and for each subgroup by periodic regression analysis with two-way ANOVA. Results showed that all diurnal IOP curves from all patients and all subgroups statistically fitted periodic regression curves within a 24-h period (p < 0.0001, two-way ANOVA for all categories). It is concluded that IOP exhibits a 24-h circadian rhythm in glaucoma patients during waking hours.