130
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Evaluation of immuno-regulatory cytokines and negative energy balance markers drift of zebu cows during the transition period

, ORCID Icon, , , , & show all
Pages 199-205 | Received 06 Feb 2019, Accepted 13 Feb 2019, Published online: 07 Mar 2019
 

ABSTRACT

Apparently healthy, eight parturient Sahiwal cows were enrolled and blood samples were collected five times: at enrolment −14, −7, 0 (day of parturition), +7, and +14 days of parturition. Another eight healthy non-pregnant Sahiwal cows in mid-lactation (>90 days of lactation) have served as standard base value control. The transition Sahiwal cows were found to have significantly lower interferon-γ (IFN-γ), and higher interleukin-10 levels at day −7, 0, +7 and +14 of parturition as compared to their own day −14 values. Significant elevation in non-esterified fatty acids (NEFA) level was estimated in these cows at the day of parturition as compared to their own day −14 values. A marked elevation in the beta-hydroxybutyrate (BHBA) level was also estimated at day 0, +7, and +14 as compared to the day −14 and −7 values in the transition cows. As compared to the standard base value, significantly lower IFN-γ and elevated IL-10 levels were estimated at day −7, 0, +7, and +14 in the transition cows. The NEFA level in the transition cows was also significantly higher at the day of parturition when compared with standard control values. In conclusion, the zebu Sahiwal cows face marked immuno-metabolic dents during the transition period.

Acknowledgments

The authors are thankful to the Hon’ble Vice Chancellor, DUVASU, for the facilities and financial assistance provided.

Disclosure statement

No potential conflict of interest was reported by the authors.

Ethical Approval

The study was in accordance with the ethical standards of the Institutional Animal Ethics Committee of U.P. Pandit Deen Dayal Upadhyaya PashuChikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU) Mathura, India.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.