Compact adaptive optics system for multiphoton fundus imaging

Josef F. Bille Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, GermanyCorrespondence[email protected]

Mikael Agopov Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Cristina Alvarez-diez Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Meng Han Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Nina Korablinova Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Ulrich von Pape Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Olivier La Schiazza Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Melanie Schwingel Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Hongwei Zhang Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

Frank Müller Kirchhoff Institute of Physics, University Heidelberg, Heidelberg, Germany

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Abstract

A compact adaptive optics system was developed and integrated into the system for multiphoton laser scanning ophthalmoscopy. Defocus, astigmatism, trefoil, and coma are compensated via a combination of telescope and rotating pairs of phase plates. The spherical aberration as well as all dynamic aberrations are corrected by an active micro-electromechanical (MEMS) mirror. Wavefront measurement is conducted by fast SHS and pyramid sensor devices. The MEMS-mirror based adaptive optics system was validated in a study on 60 eyes of 30 subjects.The adaptive-optical multiphoton ophthalmoscope is aimed at detecting the early onset of retinal diseases such as e.g. age-related macula degeneration.

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Compact adaptive optics system for multiphoton fundus imaging

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Compact adaptive optics system for multiphoton fundus imaging

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