Effect of mid-luteal phase GnRH agonist on frozen-thawed embryo transfers during natural menstrual cycles: a randomised clinical pilot study

Abstract

This prospective randomised crossover study evaluated the effect of mid-luteal single-dose gonadotropin-releasing hormone agonist (triptoreline) on pregnancy outcomes in natural-cycle frozen embryo transfers (FETs). Ninety-eight women were randomised to receive either standard luteal support with vaginal micronised progesterone or an additional single dose of 0.1 mg triptoreline at the time of implantation. The intervention group was composed of 65 FET cycles and the control group of 62 cycles. In the intervention group, there were more positive pregnancy tests, clinical pregnancies and live births, but the differences did not reach statistical significance. The mean beta human chorionic gonadotropin (β-hCG) concentration of singleton pregnancies was significantly lower in the intervention group compared to the control group (p = 0.048). No difference was detected in the median birth weight of the newborns.

Chinese abstract

这项前瞻性随机交叉研究对黄体中期单剂量促性腺激素激动剂 (曲普瑞林) 对自然月经周期中冷冻胚胎移植(FETs)妊娠结局的影响进行了评估。98名女性移植时随机给予经阴微粒化黄体酮的标准化黄体支持或标准化黄体支持的同时加用0.1mg的曲普瑞林。干预组有65个FET周期, 对照组有62个FET周期。干预组的妊娠试验阳性率, 临床妊娠和活产率更高, 但差异没有统计学意义。干预组单胎妊娠的ß-人绒毛膜促性腺素的平均浓度明显低于对照组 (P = 0.048) 。新生儿出生体重中位数没有显著差异。

Keywords:

• Clinical pregnancy
• frozen-thawed embryo transfer
• gonadotropin releasing hormone agonist
• live birth rate
• luteal support
• slow freezing

Declaration of interest

The authors have no conflicts of interest to declare. This study was funded by the University Hospital of Turku, Finland and Turku University Foundation.