The relationship between serum uric acid and metabolic syndrome in premenopausal and postmenopausal women in the Jinchang Cohort

Abstract

The aim of the study was to explore the association between serum uric acid (SUA) and metabolic syndrome (MetS) in premenopausal and postmenopausal women in the Jinchang Cohort. We studied 3808 female Jinchuan Nonferrous Metals Corporation workers aged 40–60 years. Cohort data from epidemiological surveys and medical exams were used. MetS was defined using the 2009 Joint Interim Society criteria. The relationship between SUA and MetS was evaluated using multiple logistic regression after adjusting for potential confounders. MetS and hyperuricemia were more prevalent in postmenopausal women than premenopausal ones (35.3% versus 15.2% and 9.2% versus 4.2%, respectively). Premenopausal and postmenopausal women with hyperuricemia had 2.81 (95% CI: 1.72–4.61) and 2.10 (95% CI: 1.44–3.08), respectively, times the odds of having MetS than their counterparts without hyperuricemia. Even within normal SUA quartiles, only premenopausal women in the highest and second-highest quartile had 3.57 (95% CI: 2.24–5.68) and 2.78 (95% CI: 1.71–4.50), respectively, times the odds of having MetS than those in the lowest quartile. Even in the normal range, the odds ratios for MetS increased gradually according to SUA levels in all women (P_trend<0.001). In conclusion, there was a significant correlation between SUA levels and MetS, and the association was stronger in premenopausal women than postmenopausal ones.

Chinese abstract

本研究目的为探索金昌队列中绝经前、后期女性的血清尿酸浓度(SUA)与代谢综合征(MetS)之间的关联。对金川有色金属公司3808名、年龄在40-60岁之间的女性工人进行研究。队列数据通过流行病学调查和医学检查获得。代谢综合征的诊断采用2009年国际多学会联合声明(JIS)标准。在调整潜在混杂因素后, 应用多因素logistic回归评估代谢综合征与血清尿酸浓度之间的关系。结果表明, 与绝经前女性相比, 绝经后女性更易患有代谢综合征和高尿酸血症, 分别为35.3%对15.2%和9.2%对4.2%。与绝经前、后尿酸值正常的女性相比, 伴有高尿酸血症的女性患代谢综合征的几率呈倍数增加, 优势比分别为2.81 (95% CI: 1.72–4.61)和2.10 (95% CI: 1.44–3.08)。而在血清尿酸值正常的绝经前女性中, 处于第三、第四四分位数内的女性患有代谢综合征的优势分别为在第一四分位数内者的3.5倍(95% CI: 2.24–5.68)和2.78倍(95% CI: 1.71–4.50)。即使在正常范围内, 患代谢综合征的优势比依然会随着血清尿酸值的改变而有所增加(P_trend<0.001)。综上所述, 绝经前、后女性血清尿酸值与代谢综合征存在明显的相关性, 且该相关性在绝经前期女性中更为明显。

Keywords:

• Jinchang Cohort
• metabolic syndrome
• postmenopausal
• premenopausal
• uric acid

Acknowledgements

We would like to thank the team of graduate students and professors at the Lanzhou University School of Public Health Department of Epidemiology and Biostatistics for efforts in the collection and management of epidemiological data, and the Jinchuan Nonferrous Metals Corporation for their cooperation.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

This study received financial support from the Project of Science and Technology of the Jinchuan Nonferrous Metals Corporation (JKB20120013).