The association between serum ghrelin levels and large-for-gestational-age fetuses in patients with gestational diabetes mellitus

Abstract

We aimed to determine the relationship between serum ghrelin levels and large-for-gestational-age (LGA) fetuses in patients with gestational diabetes mellitus (GDM). A case-control study was conducted in 32 women with GDM and LGA fetuses (GDM + LGA group), 35 women with GDM and appropriate-for-gestational-age (AGA) fetuses (GDM + AGA group), 32 women with normal glucose tolerance (NGT) and LGA fetuses (NGT + LGA group), and 31 women with NGT and AGA fetuses (NGT + AGA group). All participants were recruited at the time of GDM diagnosis between 24 and 30 weeks of pregnancy. Participants also underwent ultrasonographic examinations. Serum ghrelin levels were significantly higher in GDM + LGA and GDM + AGA groups than in the NGT + AGA group. In the univariate model, biparietal diameter, head circumference, abdominal circumference (AC), femur length and ghrelin values were significant predictors of LGA fetuses. In the multivariate model, only AC remained as a predictor of LGA fetuses.

Chinese abstract

我们的目的是确定血清生长素释放肽水平与妊娠期糖尿病 (GDM) 患者 (LGA) 胎儿之间的关系。采取病例对照研究, GDM伴LGA胎儿 (GDM + LGA组) 孕妇32名, GDM伴适于胎龄 (AGA) 胎儿 (GDM + AGA组) 孕妇35名, 具有糖耐量正常 (NGT) 伴LGA胎儿 (NGT + LGA组) 孕妇32名, 以及NGT伴AGA胎儿 (NGT + AGA组) 孕妇31名组成病例对照。所有参与者在妊娠24〜30周的诊断GDM时被招募。同时还接受了超声检查。 GDM + LGA和GDM + AGA组的血清生长素释放肽水平显着高于NGT + AGA组。 在单变量模型中, 双顶径, 头围, 腹围 (AC) , 股骨长度和生长素释放肽值是LGA胎儿的有效预测因子。在多变量模型中, 只有AC是LGA胎儿的预测因子。

Keywords:

• Gestational diabetes mellitus
• ghrelin
• glucose intolerance
• large-for-gestational-age fetus

Declaration of interest

The authors report no conflicts of interest.