Ovarian endometriosis and vitamin D serum levels

Abstract

Aim: The aim of this study was to assess the vitamin D serum level in women with ovarian endometriosis; specifically, a possible correlation between the dimensions of ovarian endometriomas and vitamin D serum levels was evaluated.

Materials and methods: This was an observational study of childbearing-age women diagnosed with singleton ovarian endometrioma from January 2015 to December 2015. Women diagnosed with multiple ovarian endometriomas or extraovarian endometriosis were excluded.

Results: Forty-nine women constituted the initial study cohort. In these women, the mean (±SD) 25-OH-D3 serum level was 22.0 (±8.9) ng/ml, and 42 of them (85.7%) were diagnosed with hypovitaminosis D. In the “hypovitaminosis D women”, the mean (± SD) diameter of ovarian endometriomas was 40.2 ± 22.6 mm, while in the “normal vitamin D serum level women” it was 26.7 ± 12.1 mm (p = 0.1). However, a significant linear correlation between 25-OH-D3 serum level and the diameter of ovarian endometriomas was found (r = −0.3, p = 0.03).

Conclusion: We found a relatively high rate of women with ovarian endometriosis and hypovitaminosis D. Interestingly, a significant linear correlation between 25-OH-D3 serum levels and the diameter of ovarian endometrioma emerged.

Chinese abstract

目的: 本研究目的是评估卵巢子宫内膜异位症女性的血清维生素D水平；具体来说是评估卵巢子宫内膜异位囊肿的大小和血清维生素D水平之间可能的相关性。

材料与方法: 这是一项关于2015年1月至2015年12月被诊为单发卵巢子宫内膜异位囊肿的育龄女性的观察性研究。被诊为多发卵巢子宫内膜异位囊肿或卵巢外子宫内膜异位症的女性被排除在外。

结果: 49名女性组成最初的研究队列。在这些女性中, 血清25-OH-D3的均数 (±标准差) 为22 (±8.9) ng/ml, 其中42位 (85.7%) 被诊为维生素D缺乏。在”维生素D缺乏女性”中, 卵巢子宫内膜异位囊肿直径的均数 (±标准差) 为40.2 ± 22.6mm, 而”正常血清维生素D水平女性”是26.7 ± 12.1mm (P = 0.1) 。然而, 25-OH-D3的血清水平与卵巢子宫内膜异位囊肿的直径有显著的线性相关关系 (r=-0.3, P = 0.03) 。

结论: 卵巢子宫内膜异位症和维生素D缺乏相对较高的发生率。有趣的是, 25-OH-D3的水平与卵巢子宫内膜异位囊肿的直径有显著的线性相关关系。

Keywords:

• Endometriosis
• hypovitaminosis D
• ovarian endometrioma
• vitamin D

Declaration of interest

All authors know and comply with the Journal’s Conflict of Interest Policy. The present article is not under consideration for publication elsewhere. No conflicts of interest are declared. No sources of financial support are declared.