A case of repeated mixed mood episodes with psychotic symptoms associated with the premenstrual period in a patient with polycystic ovarian syndrome

Abstract

Studies have demonstrated that estrogen plays an important role in psychotic and mood disorders in women. Estrogens have a protective effect against the development of these disorders, while hypoestrogenic states may be a risk factor for the development or exacerbation of mental illness. Additionally, women with menstrual cycle abnormalities such as those with a history of anovulation may be more susceptible to monthly estrogen level fluctuation-related mood and psychotic symptoms. We present the case of a young woman with polycystic ovarian syndrome, who experienced three episodes of premenstrual mixed mood and psychotic symptoms.

Chinese abstract

已有研究证实雌激素在调节女性精神及情绪异常中起到重要作用。雌激素对于延缓或抑制精神及情绪等异常发展具有一定的保护作用, 而低雌激素状态则有可能导致或加重精神异常。此外, 出现经期异常如无排卵女性可能更易受每月雌激素水平波动的影响从而产生情绪和精神症状。本病例报道是关于一名经历3次月经前期情绪和精神变化并出现相关症状的年轻多囊卵巢综合征患者

Keywords:

• Polycystic ovary syndrome
• central nervous system
• estrogens

Disclosure statement

Drs. Jalnapurkar and Findley have no conflicts of interest to disclose.