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Abstract
Introduction: Polycystic ovary syndrome (PCOS) patients, frequently develop metabolic complications, such as insulin resistance (IR), impaired carbohydrate metabolism, dyslipidemia, obesity. Among the new markers responsible for metabolic disorders, preptin seems to be of great significance.
Material: One hundred and thirty-four women aged 17–45 were enrolled. PCOS was diagnosed in 73 women on the basis of ESHRE-ASRM criteria. Non-PCOS group consisted of 61 women with regular menstruation matched for nutritional status.
Methods: All women underwent anamnesis, physical examination, anthropometric measurements, the abdominal ultrasound examination, and dual energy X-ray absorptiometry (DXA). Serum adropin levels were determined by ELISA. Biochemical and hormonal (testosterone, androstenedione, LH, FSH, estradiol) measurements were also performed. Insulin resistance indices (HOMA, QUICKI, Matsuda) and free androgen index (FAI) were calculated with the test results according to the standard formula. For all comparisons, statistical significance was defined by p ≤ .05.
Results: Serum preptin levels were significantly higher in the PCOS group. No significant correlations between preptin level and metabolic and hormonal markers were observed. The logistic regression analysis demonstrated that serum preptin level was an independent factor differentiating the two groups.
Conclusions: Serum preptin levels were significantly higher in women with PCOS compared with controls. This peptide might be an independent predictor of PCOS in the future.
Chinese abstract
背景：多囊卵巢综合征（PCOS）患者多伴有代谢类疾病如胰岛素抵抗（IR）、糖代谢障碍、血脂异常及肥胖等。Preptin在新发现的代谢异常疾病标志物中, 作用更为重大。
研究内容：本研究共纳入年龄在17-45岁之间的女性134名。参考欧洲人类生殖与胚胎学会（ESHRE）/美国生殖医学学会（ASRM）对PCOS的诊断标准, 其中73名女性被诊断为PCOS患者。61名有规律月经且符合营养状况要求的女性纳入非PCOS组。
方法：对所有患者询问既往史, 进行体格检查、体格指标测量、腹部超声检查和双能X线吸收法（DXA）检测。ELISA法检测患者血清adropin水平。检测患者生化和激素（睾酮、雄烯二酮、黄体生成素LH、卵泡刺激素FSH、雌二醇）水平。根据标准公式计算胰岛素抵抗指数（HOMA稳态模型, QUICKI法, Matsuda法）和游离睾酮指数（FAI）。所有数据比较结果在p ≤ 0.05时有统计学意义。
结果：PCOS组患者血清preptin水平显著升高。而preptin水平与代谢和激素指标水平无明显相关。Logistic回归分析结果表明血清preptin水平是区别两组患者的独立指标。
结论：与对照组相比, PCOS组患者血清preptin水平明显升高。在未来可考虑将该多肽类激素作为PCOS的独立预测指标。
Disclosure statement
The authors report no conflict of interests.