Abstract
This study aimed to determine whether the ovaries synthesize estradiol (E2), testosterone (T), and androstenedione (A) after menopause. The first group (30 patients) underwent surgical menopause (SM) – their ovaries were removed due to a benign condition around the time of menopause. The second group (30 patients) consisted of patients with natural menopause (NM). The E2 median level was 10.0 pg/ml (CI ± 2.18) and 9.5 pg/ml (CI ± 1.63) in the NM and SM groups (p = .69), respectively. The median level of total T was 0.12 ng/ml (CI ± 0.01) and 0.11 ng/ml (CI ± 0.03) in NM and SM, respectively (p = .96). The median level of A was 783.85 pg/ml (CI ± 154.39) and 883.48 pg/dl (CI ± 201.03) in NM and SM, respectively (p = .57). The FAI (free androgen index) was 1.06 (CI ± 0.24) and 1.35 (CI ± 0.68) for NM and SM, respectively (p = .98). We concluded that 5–10 years after menopause the ovaries are no longer relevant for sex steroid synthesis.
Chinese abstract
本研究旨在确定绝经后的卵巢是否仍在合成雌二醇(E2)、睾酮(T)和雄烯二酮(A)。第一组(30名患者)接受了手术绝经(SM) -在绝经前后, 因良性病变行卵巢切除。第二组(30例)由自然绝经(NM)患者组成。在自然绝经(NM)和手术绝经(SM)的组别中, 类固醇(E2)平均水平(p = 0.69)分别为10.0 pg/ml(CI ±2.18)和9.5 pg/ml(CI ±1.63), 总睾酮(T)平均水平(p = 0.96)分别为0.12 ng/ml(CI ±0.01)和0.11 ng/ml(CI ±0.03), 雄烯二酮(A)平均水平(p = 0.57)分别为是783.85 pg/ml(CI ±154.39)和154.39 pg/dl(CI ±201.03)。游离雄激素水平(FAI)(p1⁄4.98)分别为1.06(CI ±0.24)和1.35(CI ±0.68)。由此我们得出结论, 绝经5 - 10年后, 卵巢将不再会与性甾体激素合成相关。
Disclosure statement
The authors report no conflicts of interest.