Modified hMG stimulated: an effective option in endometrial preparation for frozen-thawed embryo transfer in patients with normal menstrual cycles

Abstract

To evaluate the clinical efficacy of modified human menopausal gonadotropin (hMG) stimulated, hormone replacement therapy (HRT), natural cycling and letrozole ovulation induction during endometrial preparation for frozen-thawed embryo transfer (FET) in patients with normal menstrual cycles. This retrospective analysis included a total of 5070 cycles of patients with normal menstrual patterns who underwent FET between October 2009 and September 2015. The patients were divided into four groups according to the method of endometrial preparation for FET: 1838 cycles were natural, 1666 underwent HRT, 340 underwent letrozole ovulation induction and 1226 underwent modified hMG stimulated. Reproduction-related clinical outcomes in the four groups were compared. The clinical pregnancy rates and live birth rates of patients in the modified hMG stimulated group were significantly higher than that in the other groups p < .05. While abortion rates were not significantly different among all four groups (all p >.05). Modified hMG stimulated resulted in a higher pregnancy rate compared to the other treatment groups. Therefore, modified hMG stimulated may be an effective option in endometrial preparation for FET in patients with normal menstrual cycles.

Chinese abstract

目的：评估改良人绝经期促性腺激素、激素替代治疗、自然周期、来曲唑促排卵在正常月经周期患者行冻融胚胎移植(FET)内膜准备的有效性。本文为回顾性分析, 共纳入了2009年10月到2015年9月5070例行FET的正常月经周期病例。根据FET内膜准备方案不同分为四组：1838 例为自然周期, 1666 例为激素替代, 340例为来曲唑促排卵, 1226例为改良的hMG刺激方案。比较四组的生育结局。改良的hMG刺激方案组的妊娠率和活产率明显高于其他组p<.05。 然而流产率四组无显著性差异 (all p>.05)。改良的hMG刺激方案妊娠率高于其他组。因此, 改良的hMG刺激方案是一种有自然周期的FET患者内膜准备的有效方案。

Keywords:

• hMG
• letrozole
• frozen-thawed embryo transfer
• hormone replacement therapy (HRT)

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This work was supported by the Guangxi Zhuang Autonomous Region Health and Family Planning Research Project [Z2015177]; the Guangxi Liuzhou Science Research and Technology Development Project [2016G020216].