The relationship between gestational diabetes mellitus and selenoprotein-P plasma 1 (SEPP1) gene polymorphisms

Abstract

Our aim is to demonstrate any correlation between gestational diabetes mellitus (GDM) and polymorphism of the selenoprotein P (SEPP1) gene encoding the SEPP1 protein, having a role in the insulin resistance in GDM. Forty pregnant women with GDM and 40 healthy pregnant women were included in the study. In both groups, single nucleotide polymorphisms (SNPs), specifically, rs4987017, rs13154178, rs146125471, rs28919926, and rs16872762 were studied. There was no difference between the groups in terms of polymorphism rs146125471, rs28919926, or rs16872762 (p > .05). There was a significant difference in SNP rs13154178 polymorphism between the two groups (p < .01). When rs13154178 gene polymorphism was compared with AA homozygous individuals, fasting blood glucose levels were significantly higher in carriers of either polymorphism than in those with no polymorphism (p < .001). We suggest rs13154178 gene polymorphism may lead to GDM in the Turkish society.

Chinese abstract

我们的目的是证明妊娠期糖尿病（GDM）和编码SEPP1蛋白的硒蛋白P（SEPP1）基因多态性之间的任何相关性, SEPP1蛋白在GDM中具有胰岛素抵抗的作用。40名GDM孕妇和40名健康孕妇被列入研究。在两组中, 均研究了单核苷酸多态性（SNPs）, 具体包括rs4987017, rs13154178, rs146125471, rs28919926和rs16872762。多态性rs146125471, rs28919926和rs16872762在两组之间的差异性无显著性（p> .05）。多态性SNP rs13154178在两组之间的差异有显著性（p <.01）。与AA纯合子个体相比, 空腹血糖水平在rs13154178多态性基因携带者中比未携带者中更高, 差异有显著性意义（p <.001）。 我们的研究指出, 在土耳其, rs13154178基因多态性可能导致GDM。

Keywords:

• Gestational diabetes mellitus
• selenoprotein P (SEPP1)
• single nucleotide polymorphism

Disclosure statement

The authors have no conflict of interest.

Additional information

Funding

This study was supported by the Mugla Sitki Kocman University Scientific Research Project Office.