Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion

Abstract

Background and aim: Insulin resistance (IR) was recognized as a risk factor for the occurrence of abortion in patients with polycystic ovary syndrome (PCOS). Chemerin was an adipokine which could induce IR and associated with reproductive process closely. However, few studies have inquired the relativity between chemerin and the occurrence of abortion in patients with PCOS. The aim of this study was to evaluate the relationship between serum chemerin and the occurrence of abortion in women with PCOS.

Methods: We recruited 198 women with PCOS to participate in our study. On the third day of menstrual cycle or a random day in women with amenorrhea, we obtained their venous blood and measured the fasting insulin, fasting plasma glucose, total cholesterol, high density lipoprotein cholesterol, triglyceride, chemerin, and hormones including FSH, E2, P, PRL, LH, and T. Additionally, BMI, HOMA-IR and LH/FSH of each subject were calculated. Finally, 58 of them were included in the study, in which 30 of them had normal pregnancy and the other 28 had an early miscarriage. We compared the biochemical characteristics between the normal pregnancy group and abortion group by independent-samples t test.

Results: In our study, those with a normal pregnancy had a lower level of BMI, FINs, HOMA-IR, and chemerin compared to abortion patients (p < .05). After adjusted for BMI, only chemerin was associated with the occurrence of abortion in PCOS patients (p < .05).

Conclusions: Serum chemerin level is associated with the occurrence of abortion in patients with PCOS. Thus, serum chemerin may serve as a biomarker to identify pregnant women with PCOS who are at particular risk for later abortion, and who may benefit from prevention strategies.

Chinese abstract

背景与目的：胰岛素抵抗（IR）是多囊卵巢综合征（PCOS）患者发生流产的危险因素。Chemerin是一种能诱导IR并与生殖过程密切相关的脂肪因子。然而, 很少有研究探讨Chemerin与PCOS患者发生流产的相关性。本研究的目的就是评估血清Chemerin与多囊卵巢综合征妇女流产的关系。

方法：我们招募了198名PCOS妇女参与我们的研究。在月经周期的第三天或闭经患者的随机日, 抽取静脉血, 测量空腹胰岛素、空腹血糖、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、Chemerin以及FSH、E2、P、PRL、LH、T等激素水平。另外, 计算每个受试者的体重指数（BMI）、稳态模型评估胰岛素抵抗指数（HOMA-IR）和LH/FSH比值。在经过促排卵治疗后, 58例妇女获得妊娠, 其中30例为正常妊娠, 28例为早期流产。采用独立样本t检验比较正常妊娠组与流产组的生化指标。

结果：研究中, 我们发现与流产组相比, 正常妊娠组BMI、空腹胰岛素、HOMA-IR、Chemerin水平均较低（P＜.05）。在校正BMI后, 仅有Chemerin与PCOS患者发生流产相关（P＜.05）。

结论：血清Chemerin水平与多囊卵巢综合征患者流产的发生有关。因此, Chemerin可作为那些有着较高流产风险的PCOS孕妇的生物标记, 使得她们可以从相应的预防策略中获益。

Keywords:

• Chemerin
• polycystic ovarian syndrome (PCOS)
• insulin resistance
• miscarriage

Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

This work was supported by Natural Science Foundation of Hubei Province of China [2018CFB472], Special Fund for Clinical Research of Chinese Medical Association–a research and development project of reproductive medicine for young physician [17020130682], Traditional Chinese Medicine and Western Medicine combined Research Program of Health and Family Planning Commission of Hubei Province and Xiangyang City’s high level medical talents support program.