Chronological age vs biological age: a retrospective analysis on age-specific serum anti-Müllerian hormone levels for 3280 females in reproductive center clinic

Abstract

The aim of the present study was to determine the correlation between chronological age and biological age by characterizing age-specific serum anti-Müllerian hormone (AMH) values for 3280 Chinese women. A retrospective analysis including 3280 females between 10 to 52 years old was conducted from January 2016 to December 2016 in the clinical laboratory of Center for Reproductive Medicine, The Third Affiliated Hospital of Sun Yat-sen University, China. All included women were divided into several groups by age. Distribution and Statistical description of age-specific AMH levels was provided. Our results showed that serum AMH levels were negatively correlated with age (r = −0.606, p < .001). AMH concentrations approximately 31.1% depended on age and descended by an average of 6.2% per year. Around 25, 35 and 40 years, the decrease of AMH values accelerated. In conclusion, biological age was inversely correlated with chronological age. The present data can provide information for evaluating the fertility potential and ovarian reserve of infertile patients, as well as facilitate clinicians to decide individual treatment options.

Chinese abstract

本研究的目的为通过测定3280名中国女性的年龄特异性血清抗苗勒管激素（AMH）水平, 确定实际年龄与生物学年龄的相关性。研究回顾性分析了2016年1月至2016年12月, 在中国中山大学附属第三医院生殖医学中心临床实验室共计3280名10至52岁女性。所有入组女性基于年龄分为若干组。对年龄特定AMH水平进行分布和统计描述。研究显示血清AMH水平与年龄呈负相关（r = -0.606, p < .001）。AMH浓度约为31.1％, 取决于年龄, 并平均每年下降6.2％。大约在25岁、35岁及40岁, AMH的水平下降加速。总之, 生物学年龄与实际年龄呈负相关。目前的数据可为不孕患者提供评估生殖潜力与卵巢储备的信息, 且可促进临床个体化治疗的选择。

Keywords:

• Anti-Müllerian hormone
• age
• ovarian reserve
• infertility

Disclosure statement

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors report no financial or commercial conflicts of interest.