Predictive value of basal androgen levels on ongoing pregnancy rates during in vitro fertilization cycles

Abstract

We aimed to evaluate the impact of elevated basal androgen levels on the endometrial receptivity. This study retrospectively enrolled 5278 fresh in vitro fertilization (IVF) cycles and sought to determine whether increased basal androgen levels are associated with adverse outcomes in regard to ongoing pregnancy rates. The results showed that the average age of our sample was 29.31 years. Almost 61.6% of all embryo transfers were with Day 3 embryos and the remaining 38.4% were with Day 5 embryos. The ongoing pregnancy rate was 56.4%. The ongoing pregnancy rates according to the various ordinal serum androgen intervals (<10.00, 10.00–19.99, 20.00–29.99, 30.00–39.99, and ≥40.00 ng/dL) were 60.12, 56.62, 58.64, 55.48, and 50.17%, respectively. The ongoing pregnancy rates were significantly lower in patients with high basal androgen levels (e40 ng/dL) (p < .05). Multivariate regression analysis showed that age, BMI, and endometrial thickness were inversely associated with basal androgen levels (p < .0001 for all). In conclusion, elevated serum basal androgen levels on cycle Day 3 before IVF is associated with reduced ongoing pregnancy rates.

Chinese abstract

我们旨在评估基础雄激素水平升高对子宫内膜容受性的影响。本研究回顾性研究了5278例体外受精(IVF)周期, 探讨基础雄激素水平的升高是否与持续妊娠率的不良结局相关。结果显示, 样本的平均年龄为29.31岁。其中61.6%的胚胎移植是在第三天胚胎, 其余38.4%是第5天胚胎。持续妊娠率为56.4%。根据血清雄激素水平分组后其持续妊娠率 (< 10.00, 10.00-19.99, 20.00 -29.99, 10.00 - 10.00和≥40.00 ng/dL)分别为60.12, 56.62, 58.64, 55.48和50.17%。高基础雄激素水平(e40 ng/dL)患者的持续妊娠率明显降低(p<.05)。多元回归分析显示, 年龄、BMI和子宫内膜厚度与基础雄激素水平均成反比(p<.0001)。综上所述, 体外受精前周期第3天的基础雄激素水平升高与持续妊娠率降低相关。

Keywords:

• Basal androgen levels
• ongoing pregnancy
• endometrial receptivity
• IVF/ICSI

Disclosure statement

No potential conflict of interest was reported by the authors.