Evaluation of ovarian reserve in women with psoriasis

Abstract

The aim of this study is to evaluate ovarian reserve in women with psoriasis. Thirty-six women with psoriasis and 36 healthy women were enrolled in this prospective study. On day 3 of the menstrual cycle, blood samples for AMH and other hormones were collected. On the same day, antral follicle count (AFC), and ovarian volumes were measured. A multiple regression analysis was carried out to examine the contribution of factors to the serum AMH levels in patients with psoriasis. The serum AMH levels and ovarian volumes were lower in the psoriasis group than in the control group (1.85 ± 1.13 ng/ml vs 2.46 ± 1.21 ng/ml, p = .029 and 10.43 ± 3.08 cm³ vs 11.93 ± 3.01 cm³, p = .038). However, the mean AFC between the two groups was not significantly different. The psoriasis area severity index (PASI) score did not correlate with AMH. On the other hand, the duration of the disease negatively correlated with AMH, total AFC and ovarian volume. In the multiple regression analysis, duration of disease and total AFC were the most significant contributors to the serum AMH levels in patients with psoriasis. Autoimmune diseases may affect ovarian reserve regardless of immunosuppresive treatment. Longitudinal follow-ups regarding reproductive function might be required in women with psoriasis.

Trial registration: ClinicalTrials.gov identifier: NCT03492632.

摘要

本研究的目的是评估银屑病女性的卵巢储备。该项前瞻性研究纳入了36例银屑病患者和36例健康女性。在月经周期的第三天, 搜集血样检测AMH和其他激素。同一天, 检测窦卵泡数（AFC）和卵巢体积。采用多元回归分析方法, 探讨影响银屑病患者血清AMH水平的因素。银屑病组血清AMH水平和卵巢体积低于对照组(1.85 ± 1.13ng/ml vs 2.46 ± 1.21ng/ ml, p=.029 和10.43 ± 3.08cm3 vs 11.93 ± 3.01cm3, p=.038)。两组间AFC均值无显著性差异。银屑病严重程度指数（PASI）评分与AMH无相关性。另一方面, 病程与AMH、AFC总数、卵巢体积呈负相关。在多元回归分析中, 病程和总AFC对银屑病患者血清AMH水平影响最大。无论采用何种免疫抑制治疗, 自身免疫疾病都可能影响卵巢储备。对于患有银屑病的女性可能需要进行生殖功能方面的随访。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Ovarian reserve
• psoriasis
• anti-mullerian hormone
• antral follicle count

Disclosure statement

No potential conflict of interest was reported by the authors.