Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls

Abstract

This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12 months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p = .005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p < .05), while the MKRN3 concentrations were unchanged (p > .05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r = −0.46, p = .000), SD in weight (r = −0.32, p = .005), Tanner stage (r = −0.41, p = .000), and bone age (r = −0.46, p = .000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation

摘要

本研究检测了血清MKRN3水平, 并探讨了其对女童性早熟(CPP)的诊断价值。共纳入41例CPP女童和35例年龄匹配的正常对照组女童。测定两组患者血清MKRN3水平。在CPP患者接受GnRH激动剂 (GnRHa) 治疗6个月和12个月后, 评估促性腺激素和雌二醇的浓度。CPP组MKRN3浓度明显低于对照组(p = .005)。对于超过1年的GnRHa治疗患者,促性腺激素浓度明显下降(p < . 05), 而MKRN3浓度保持不变(p > . 05)。MKRN3水平与身高(r = 0.46, p=.000)、体重(r = 0.32, p=.005)、唐纳分期(r = 0.41, p=.000)和骨龄(r = 0.46, p=.000)的标准差呈负相关。根据ROC分析, MKRN3的曲线下面积为0.758, 敏感性为82.9%, 特异性为68.5%。测量血清MKRN3水平可能为CPP预测提供一定的帮助, 但尚需要进一步验证。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Precocious puberty
• MKRN3
• biomarker

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the Hallym University Research Fund 2014 [HURF-2014-23].