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Abstract
To evaluate the effect of empiric intralipid infusion therapy on pregnancy outcomes for patients with unexplained recurrent implantation failure (RIF) undergoing intracytoplasmic sperm injection (ICSI). A total of 142 patients with a history of unexplained RIF (3 or more cycles) were included in this randomized controlled trial. Patients were randomized into two groups, study group (n = 71) and control group (n = 71). The study group received intralipid 20% infusion on the day of embryo transfer (ET) and a second dose on the day of pregnancy test. The clinical pregnancy rate in the study group was 36.6% (n = 26) compared to 28.2% (n = 20) in the control group (OR 1.47, CI 0.72–2.98, p = .282). The live birth rate in the study group was 18.3% (n = 13) and 14.1% (n = 10) in the control group (OR 1.37, CI 0.55–3.36, p=.49). No side effects of intralipid therapy were reported in the study period. There was improvement in the pregnancy rate among women with unexplained RIF who received empiric intralipid infusion therapy; however, this improvement did not reach statistical significance.
摘要
本研究目的是探讨经验性脂肪乳静脉滴注治疗对不明原因反复种植失败（RIF）患者卵胞浆内单精子注射（ICSI）妊娠结局的影响。本次随机对照试验共纳入142名有不明原因RIF（3次及以上）病史的患者。患者被随机分为两组, 研究组（n=71）和对照组（n=71)。研究组于胚胎移植当天（ET）接受20%的脂肪乳静脉滴注, 妊娠试验当天进行第二次滴注。研究组临床妊娠率为36.6%（n=26）, 对照组为28.2%（n=20）(OR 1.47, CI 0.72–2.98, p=.282)。研究组的活产率为18.3%（n=13）对照组为14.1（n=10）(OR 1.37, CI 0.55–3.36, p=.49)。研究期间未见脂肪乳治疗的副作用。原因不明的RIF患者接收经验性脂肪乳静脉滴注治疗后妊娠率有改善, 然而, 这一改善并无统计学意义。
Acknowledgments
The authors would like to thank Mr. Mohammed Bashir for his statistical analysis and the research center at King Fahad Medical City.
Disclosure statement
The authors have nothing to disclose and no conflict of interest.