Relationship between early follicular serum estrone level and other hormonal or ultrasonographic parameters in women with polycystic ovary syndrome

Abstract

The aim of this study was to investigate the relationship between serum estrone (E1) level and other cardinal features in women with polycystic ovary syndrome (PCOS). 133 Korean women aged 18–35 years who were newly diagnosed with PCOS at a university hospital were included in the present study. Blood samples were collected from all participants during the early follicular phase to determine the serum E1 level and other biochemical hormonal parameters. The total antral follicle count (TFC) and the total ovarian volume (TOV) were assessed using transvaginal or transrectal ultrasound. A significant correlation was found between serum E1 and luteinizing hormone (LH) levels in women with PCOS. In addition, statistically significant correlations were observed between serum E1 level and other hormonal parameters, including testosterone, free testosterone, dehydroepiandrosterone sulfate, and 17α-hydroxyprogesterone. With respect to the ultrasound features, serum E1 levels were significantly correlated with TFC and TOV. All results did not change after adjusting for body mass index (BMI). In conclusion, serum E1 level is significantly correlated with serum LH and androgen levels, and it may be a useful marker for representing the status of the ovarian volume in women with PCOS.

摘要

本研究的目的是调查多囊卵巢综合征（PCOS）患者的血清雌酮（E1）水平与其他基本特征之间的关系。本研究包括133例在大学医院新诊断为PCOS的18-35岁韩国女性。在卵泡早期, 从所有参与者中收集血液样本, 以确定血清E1水平和其他生化激素参数。经阴道或经直肠超声评估总的窦卵泡计数（TFC）和总的卵巢体积（TOV）。在患有PCOS的女性中, 血清E1与促黄体生成素（LH）水平之间存在显著相关性。此外, 观察到血清E1水平和其他激素参数（包括睾酮, 游离睾酮, 硫酸脱氢表雄酮和17a-羟孕酮）之间有统计学上显著的相关性。关于超声特征, 血清E1水平与TFC和TOV显著相关。调整体重指数（BMI）后, 所有结果均未改变。总之, 血清E1水平与血清LH和雄激素水平显著相关, 并且它可能是代表PCOS女性卵巢体积状态的一个有用指标。

Keywords:

• Estrone
• polycystic ovary syndrome
• luteinizing hormone
• androgen
• ovarian volume

Declaration of interest

The author reports no declaration of interest.